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Peripheral Artery Disease: causes and consequences

Coronary Artery Disease: causes and consequences

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Coagulation Cascade

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Anticoagulants - coagulation cascade

Vitamin K antagonists lower levels of factors II, VII, IX and X. The heparins and fondaparinux work...

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Cascade overview

An overview of the coagulation cascade, showing the initiation, propagation, and clot formation phases

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Clotting formation - coagulation cascade

Thrombin converts fibrinogen to fibrin monomers which polymerize to form fibrin strands, Factor XIII...

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Fibrinolysis

Plasminogen activators from injured endothelium convert plasminogen to plasmin which in turn breaks up the...

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Initiation - coagulation cascade

Clotting is initiated by the activation of Factor VII by membrane-bound tissue factor. This leads to...

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Natural inhibitors

The natural inhibitors of coagulation include tissue factor pathway inhibitor (TFPI), activated protein C...

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Propagation - coagulation cascade

Activated Factor X, functioning as part of the prothrombinase complex on the surface of activated...

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