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Real World Evidence and Claims Databases – a Guide for Healthcare Professionals
Prof. Craig I. Coleman gives an appreciation of the methodology used to perform Real World Evidence studies, particularly those investigating the effectiveness and safety, of non-vitamin K antagonist oral anticoagulants (or NOACs) in non-valvular atrial fibrillation patients. He also provides some key insights on what real world evidence and specifically claims databases can - and cannot - tell us. Approval number: PP-XAR-ALL-0036-2
For more information visit:
Centre for Outcomes Research (Accessed 9 November 2020)
GRACE risk score calculator (Accessed 9 November 2020)
Related key publications:
Luo J, Dai L, Li J et al. Risk evaluation of new-onset atrial fibrillation complicating ST-segment elevation myocardial infarction: a comparison between GRACE and CHA2DS2-VASc scores. Clin Interv Aging 2018;13:1099–1109.
Akyuz S, Yazici S, Bozbeyoglu E et al. Validity of the updated GRACE risk predictor (version 2.0) in patients with non-ST-elevation acute coronary syndrome. Rev Port Cardiol 2016;35:25–31.
Fox KAA, Fitzgerald G, Puymirat E et al. Should patients with acute coronary disease be stratified for management according to their risk? Derivation, external validation and outcomes using the updated GRACE risk score. BMJ Open 2014;4:e004425.
Fox KAA, Dabbous OH, Goldberg RJ et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). BMJ 2006;333:1091.
Eagle KA, Lim MJ, Dabbous OH et al. A validated prediction model for all forms of acute coronary syndrome: estimating the risk of 6-month postdischarge death in an international registry. JAMA 2004;291:2727–2733.
Granger CB, Goldberg RJ, Dabbous O et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med 2003;163:2345–2353.
Publications utilizing GRACE registry data
GRACE bibliography (Accessed 9 November 202009/11/2020)
Related key publications:
Mandelzweig L, Battler A, Boyko V et al. The second Euro Heart Survey on acute coronary syndromes: characteristics, treatment, and outcome of patients with ACS in Europe and the Mediterranean basin in 2004. Eur Heart J 2006;27:2285–2293.
Hasdai D, Behar S, Wallentin L et al. A prospective survey of the characteristics, treatments and outcomes of patients with acute coronary syndromes in Europe and the Mediterranean basin; the Euro Heart Survey of Acute Coronary Syndromes (Euro Heart Survey ACS). Eur Heart J 2002;23:1190–1201.
For more information visit:
National Cardiovascular Data Registry (Accessed 9 November 2020)
Related key publications:
Basra SS, Wang TY, Simon DN et al. Ticagrelor use in acute myocardial infarction: insights from the National Cardiovascular Data Registry. J Am Heart Assoc 2018;7:e008125.
Bradley SM, Hess GP, Stewart P et al. Implications of the PEGASUS-TIMI 54 trial for US clinical practice. Open Heart 2017;4:e000580.
Desai NR, Kennedy KF, Cohen DJ et al. Contemporary risk model for inhospital major bleeding for patients with acute myocardial infarction: the Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry®-Get With The Guidelines (GWTG)®. Am Heart J 2017;194:16–24.
Pokorney SD, Miller AL, Chen AY et al. Reassessment of cardiac function and implantable cardioverter-defibrillator use among Medicare patients with low ejection fraction after myocardial infarction. Circulation 2017;135:38–47.
Smilowitz NR, Mahajan AM, Roe MT et al. Mortality of myocardial infarction by sex, age, and obstructive coronary artery disease status in the ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines). Circ Cardiovasc Qual Outcomes 2017;10:e003443.
Vora AN, Wang TY, Li S et al. Selection of stent type in patients with atrial fibrillation presenting with acute myocardial infarction: an analysis from the ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry-Get With The Guidelines. J Am Heart Assoc 2017;6:e005280.
Yu T, Tian C, Song J et al. ACTION (acute coronary treatment and intervention outcomes network) registry-GWTG (get with the guidelines) risk score predicts long-term mortality in acute myocardial infarction. Oncotarget 2017;8:102559–102572.
Mathews R, Fonarow GC, Li S et al. Comparison of performance on Hospital Compare process measures and patient outcomes between hospitals that do and do not participate in Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines. Am Heart J 2016;175:1–8.
Pandey A, McGuire DK, de Lemos JA et al. Revascularization trends in patients with diabetes mellitus and multivessel coronary artery disease presenting with non-ST elevation myocardial infarction: insights from the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines (NCDR ACTION Registry-GWTG). Circ Cardiovasc Qual Outcomes 2016;9:197–205.
Shah RU, de Lemos JA, Wang TY et al. Post-hospital outcomes of patients with acute myocardial infarction with cardiogenic shock: findings from the NCDR. J Am Coll Cardiol 2016;67:739–747.
Sutton NR, Li S, Thomas L et al. The association of left ventricular ejection fraction with clinical outcomes after myocardial infarction: findings from the Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry-Get With The Guidelines (GWTG) Medicare-linked database. Am Heart J 2016;178:65–73.
Kontos MC, Scirica BM, Chen AY et al. NCDR. Cardiac arrest and clinical characteristics, treatments and outcomes among patients hospitalized with ST-elevation myocardial infarction in contemporary practice: A report from the National Cardiovascular Data Registry. Am Heart J 2015;169:515–522.
Shavelle DM, Chen AY, Matthews RV et al. Predictors of reperfusion delay in patients with ST elevation myocardial infarction self-transported to the hospital (from the American Heart Association's Mission: Lifeline Program). Am J Cardiol 2014;113:798–802.
Desai NR, Peterson ED, Chen AY et al. Balancing the risk of mortality and major bleeding in the treatment of NSTEMI patients – a report from the National Cardiovascular Data Registry. Am Heart J 2013;166:1043-1049.
Kadakia MB, Desai NR, Alexander KP et al. Use of anticoagulant agents and risk of bleeding among patients admitted with myocardial infarction: a report from the NCDR ACTION Registry–GWTG (National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry–Get With the Guidelines). JACC Cardiovasc Interv 2010;3:1166–1177.
Peterson ED, Roe MT, Chen AY et al. The NCDR ACTION Registry-GWTG: transforming contemporary acute myocardial infarction clinical care. Heart 2010;96:1798–1802.