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Coronary Artery Disease: Causes and Consequences

Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the coronary arteries and underlies ischaemic heart disease, the leading cause of death worldwide.1,2 Rupture of an atherosclerotic plaque can lead to the formation of a blood clot in the artery.3 This is known as atherothrombosis and can lead to restricted blood flow through the artery, potentially causing myocardial infarction.4,5 Although antiplatelet therapy is available to patients with CAD, the residual risk of atherothrombotic events remains high.6,7

Causes and consequences of CAD

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Causes and consequences of CADCauses and consequences of CAD

 

An overview of coronary artery disease
PP-XAR-ALL-0080

References
  • Sanchis-Gomar F, Perez-Quilis C, Leischik R, Lucia A. Epidemiology of coronary heart disease and acute coronary syndrome. Ann Transl Med 2016;4:256. Return to content
  • World Health Organization. 2018. https://www.who.int/en/news-room/fact-sheets/detail/the-top-10-causes-of-death [accessed 26 Jun 2020]. World Health Organization. 2018. https://www.who.int/en/news-room/fact-sheets/detail/the-top-10-causes-of-death [accessed 26 Jun 2020]. Return to content
  • Libby P. Mechanisms of acute coronary syndromes and their implications for therapy. N Engl J Med 2013;368:2004–2013. Return to content
  • Thygesen K, Alpert JS, Jaffe AS et al. Third universal definition of myocardial infarction. Circulation 2012;126:2020-2035. Return to content
  • Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature 2011;473:317–325. Return to content
  • Alberts MJ, Bhatt DL, Mas JL et al. Three-year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry. Eur Heart J 2009;30:2318–2326. Return to content
  • Tendera M, Aboyans V, Bartelink ML et al. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the task force on the diagnosis and treatment of peripheral artery diseases of the European Society of Cardiology (ESC). Eur Heart J 2011;32:2851–2906. Return to content

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