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Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the coronary arteries and underlies ischaemic heart disease, the leading cause of death worldwide.1,2 Rupture of an atherosclerotic plaque can lead to the formation of a blood clot in the artery.3 This is known as atherothrombosis and can lead to restricted blood flow through the artery, potentially causing myocardial infarction.4,5 Although antiplatelet therapy is available to patients with CAD, the residual risk of atherothrombotic events remains high.6,7
Causes and consequences of CADCauses and consequences of CAD
An overview of coronary artery disease