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This section details the other options for thromboprophylaxis, including antiplatelet agents and mechanical prophylaxis
Although ASA (aspirin) is more effective than placebo in preventing VTE in high-risk patients, it is less effective than LMWH.1 There are insufficient data comparing ASA with warfarin or UFH for VTE prophylaxis, and there are currently no comparative studies with the NOACs.1 The 2012 American College of Chest Physicians (ACCP) guidelines recommend ASA, among other antithrombotics, over no prophylaxis at all, but LMWH or oral anticoagulants are preferred.2
Mechanical prophylaxis methods do reduce the risk of DVT, although they have not been studied as intensively as pharmacological options:2,3
|Elastic (graduated) compression stockings||Provide circumferential pressure that gradually decreases from the ankle to the thigh to promote venous blood flow||Studies in hip surgery,4 general surgery5 and stroke6|
|Intermittent pneumatic compression||Leggings repeatedly inflated and deflated by a pneumatic pump with the goal of mimicking natural calf muscle contractions that promote venous return||Meta-analysis of published studies5|
|Venous foot pump||Imitates the physiological pumping action of weight bearing on the venous plexus of the sole of the foot to simulate the effect of normal walking and increase venous flow||Limited|