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Peripheral Artery Disease: Causes and Consequences

Peripheral artery disease (PAD) is a progressive, systemic disease resulting from the formation of atherosclerotic plaques in the peripheral arteries, causing stenosis and occlusion.1 PAD is often asymptomatic, but severe vascular obstruction can lead to limb ischaemia requiring amputation.1 Despite receiving treatment involving antiplatelet therapy and lifestyle changes, patients with PAD are still at high risk of thrombotic events.2

Causes and consequences of PAD

YYMMDD Author/Uploaded by

An overview of peripheral artery disease pathogenesis,

epidemiology and management.


An overview of peripheral artery disease

  • Tendera M, Aboyans V, Bartelink ML et al. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: the task force on the diagnosis and treatment of peripheral artery diseases of the European Society of Cardiology (ESC). Eur Heart J 2011;32:2851–2906. Return to content
  • Alberts MJ, Bhatt DL, Mas JL et al. Three-year follow-up and event rates in the international REduction of Atherothrombosis for Continued Health Registry. Eur Heart J 2009;30:2318–2326. Return to content

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