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Peripheral artery disease (PAD) is a progressive, systemic disease resulting from the formation of atherosclerotic plaques in the peripheral arteries, causing stenosis and occlusion.1 PAD is often asymptomatic, but severe vascular obstruction can lead to limb ischaemia requiring amputation.1 Despite receiving treatment involving antiplatelet therapy and lifestyle changes, patients with PAD are still at high risk of thrombotic events.2
An overview of peripheral artery disease
Approval Number PP-XAR-ALL-0082
The development of plaques in the arteries of the lower extremities, as a consequence of the systemic disease atherosclerosis, leads to Peripheral artery disease (PAD). PAD causes a spectrum of lower limb symptoms, but can often be asymptomatic.1 Patients with PAD have a high morbidity and mortality burden due to worsening of limb symptoms (which can lead to amputation) and potentially fatal, systemic atherothrombotic events (such as MI and stroke).3
PAD treatment involves lifestyle changes, a structured exercise programme, drugs aimed at vascular protection and, in some instances, revascularization.1,4 Treatment is aimed at improving limb prognosis (improving symptoms and minimizing tissue loss) and preventing cardiovascular events (by improving cardiovascular risk factor control and preventing atherothrombosis).4 However, even with optimal treatment, which includes an antiplatelet agent and a statin, there remains a high residual risk of systemic and limb-related ischaemic events.2
Peripheral Artery Disease: Mechanism of Disease
Approval Number PP-XAR-ALL-1891-1
Over 120 million people are estimated to have peripheral artery disease worldwide,1 yet it remains both under-diagnosed and under-treated. Here, we take a look at a fictional patient – Paul – to better understand the symptoms and the long-term outcomes of this disease.
A patient’s story: CAD and PAD
Approval Number PP-XAR-ALL-1735-1
A patient’s story of their experience with coronary and peripheral artery diseases, and how new therapeutic approaches helped their treatment and recovery.