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Coronary artery disease (CAD) is characterized by atherosclerotic plaque formation in the coronary arteries and underlies ischaemic heart disease, the leading cause of death worldwide.1,2 Rupture of an atherosclerotic plaque can lead to the formation of a blood clot in the artery.3 This is known as atherothrombosis and can lead to restricted blood flow through the artery, potentially causing myocardial infarction.4,5 Although antiplatelet therapy is available to patients with CAD, the residual risk of atherothrombotic events remains high.6,7
An overview of coronary artery disease including pathogenesis and treatment.
Approval Number PP-XAR-ALL-0080
The development of plaques in the coronary arteries, as a consequence of the systemic disease atherosclerosis, leads to coronary artery disease (CAD).1,5 Patients with CAD are at high risk of potentially fatal ischaemic events caused by atherothrombosis, such as MI and stroke.6 Therefore, the mortality and morbidity burden of CAD is high.1
CAD treatment involves lifestyle changes, drugs aimed at vascular protection and, in some instances, revascularization. Treatment aims to improve symptoms, control cardiovascular risk factors and prevent ischaemic events.8 However, even with optimal treatment, which includes an antiplatelet agent and a statin, there remains a high residual risk of ischaemic events.6
Coronary Artery Disease: Mechanism of Disease
An overview of coronary artery disease development and pathogenesis
Approval Number PP-XAR-ALL-1890-1