Between 20% and 50% of patients who develop deep vein thrombosis (DVT) go on to develop post-thrombotic syndrome (PTS), a condition that is associated with substantial morbidity. Patients with PTS are generally managed using compression therapy and leg elevation, although surgical intervention may be appropriate in some cases. Chronic thromboembolic pulmonary hypertension (CTEPH) occurs as a complication in 3–4% of patients who survive pulmonary embolism (PE). Patients with CTEPH may be managed surgically via pulmonary endarterectomy or, if this is inappropriate, lung transplantation. Drugs approved for idiopathic pulmonary arterial hypertension may be useful for managing the symptoms of CTEPH in patients who are not appropriate for surgery.