Bayer Pharma AG

Essence of this Article

The oral agent dabigatran directly inhibits thrombin, which is essential for the amplification of coagulation and fibrin formation.

Direct thrombin inhibitors

The oral agent dabigatran directly inhibits thrombin:91

  • Thrombin is produced in small amounts in the initiation phase and large amounts in the propagation phase110
  • Thrombin is essential for the amplification of coagulation and fibrin formation109

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