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What might you consider in your decision whether to extend Cameron’s anticoagulation?
Every patient is different, and extended treatment should be considered based on an individual’s risk factors and characteristics.
But, the decision to extend anticoagulation beyond 6 months, however, is tailored to the individual, balancing their risk of venous thromboembolism (VTE) recurrence against their risk of bleeding, whilst taking into account patient preference.1,2
So, what is Cameron’s risk of recurrence?
Cameron has already had a recurrent DVT. Although he stopped smoking after his first DVT, his other risk factors for recurrence include his family history of VTE and long coach journeys as part of his work. Patients with minor persistent or minor transient risk factors such as these, have a risk of recurrence as high as patients without recognised risk factors.3,4
Risk of VTE recurrence is high in patients who stop anticoagulation regardless of the underlying cause3
These factors all suggest that Cameron may benefit from the extended protection that continued anticoagulation would provide. However, Cameron may be wondering if the benefits of extended anticoagulation outweigh the risks.
Several phase III studies of non-vitamin K antagonist oral anticoagulants (NOACs), rivaroxaban, apixaban, dabigatran and edoxaban, have confirmed the efficacy and safety of extended anticoagulation compared with placebo in reducing the risk of VTE recurrence in patients who were at clinical equipoise for continued therapy. Further information on these Phase III NOAC studies can be found here.
Reassuring results on the efficacy and safety of extended anticoagulation from patients treated in clinical practice has also been shown in real-world studies. Further information on relevant real-world studies can be found here.
Rivaroxaban is currently the only NOAC that allows the choice of two doses for extended treatment. For patients like Cameron who are at a reduced risk of recurrence, then the availability of a lower dose, rivaroxaban 10 mg once daily, still offers him protection from VTE recurrence, whilst maintaining a low risk of bleeding.4,5
EINSTEIN CHOICE study: Continued rivaroxaban therapy significantly reduced the rate of recurrence in patients with provoked and unprovoked VTE compared with aspirin
This provides Cameron’s doctor with the option to tailor treatment to his individual risk profile in the extended treatment period, whilst providing him with the continued convenience of a once-daily regimen. Further information on single-drug approaches for VTE can be found here.
Rivaroxaban offers a choice of two doses for extended treatment5
Looking more carefully at an individual’s risk of recurrence could help to identify patients who might benefit from extended anticoagulation.
Given the available evidence and guideline recommendations, extending treatment for patients like Cameron who are at clinical equipoise for continued anticoagulation may be beneficial. It may also provide the reassurance that individual’s like Cameron need to continue their lives, whilst not having to worry about whether they are protected from further thromboembolic events.