1. Knowledge Base
  2. Venous Thrombosis
  3. VTE in Special Populations

Welcome to the ‘Thrombosis Adviser’ Knowledge Base

This section provides an overview of the epidemiology and burden of cancer-associated thrombosis, current guideline recommendations for its prevention and treatment, and ongoing research.

Essentials

The essential guide to understanding thrombosis

Stroke Prevention

Introduction and prevention of AF-related stroke

Venous Thrombosis

Introduction, prevention and treatments for deep vein thrombosis, pulmonary embolism and venous thromboembolism

Arterial Thrombosis

Aetiology, diagnosis, treatment and prevention of acute coronary syndrome, coronary artery disease and peripheral artery disease

Glossary

Essentials

Introduction

The essential guide to understanding thrombosis

Haemostasis

An overview of haemostasis and its physiological importance

The Coagulation Cascade

Introduction

A mechanistic overview of the coagulation cascade

Factor Xa Inhibitors

The role of Factor Xa and the use of Factor Xa inhibitors as anticoagulants

Direct Thrombin Inhibitors

The role of thrombin and the use of direct thrombin inhibitors as anticoagulants

Vitamin K Antagonists

The role of Vitamin K and the use of Vitamin K antagonists as anticoagulants

Heparins

The use of heparin and its derivatives as anticoagulants

Thrombus Formation

An overview of the risk factors for thrombus formation

Venous Thrombosis

An introduction to venous thrombi with a focus on deep vein thrombosis

Arterial Thrombosis

An introduction to atherosclerosis and arterial thrombus formation

Stroke Prevention

Atrial Fibrillation-Related Stroke

Introduction

AF is a common cardiac arrhythmia and a major risk factor for stroke. Learn about its diagnosis, classification and management

Prevention

{Preventing AF-Related Stroke} {Patients with NVAF} {Patients with VAF}

Special Populations

Diabetes

Diabetes is frequently encountered in patients with AF and can worsen prognosis

Renal Impairment

Renal impairment increases the risk of stroke and bleeding in patients with AF

Worsening Renal Function

Preservation of renal function is an important consideration in patients with AF, because worsening renal function can adversely impact prognosis

Patients with AF undergoing PCI

When patients with AF require PCI, they have complex treatment needs

Venous Thrombosis

Introduction

An introduction to venous thromboembolic disorders, their incidence and prevalence, and risk factors

Deep Vein Thrombosis

Introduction and Diagnosis

An introduction to DVT and its clinical presentation and diagnosis

Pulmonary Embolism

Introduction and Diagnosis

An introduction to PE and its clinical presentation and diagnosis

Prevention

Introduction

VTE is a major healthcare burden

Anticoagulant Therapy

Anticoagulant therapy in patients with VTE

Other Options

Other options for thromboprophylaxis

Treatment

Treatment of DVT and PE

VTE in Special Populations

Patients with VTE and Renal Impairment

Patients with VTE and renal impairment are at high risk of thrombotic events

Frail and Elderly Patients with VTE

Elderly patients with frailty are at increased risk of thrombotic events. Treatment outcomes with non-vitamin K antagonist oral anticoagulants (NOACs) from clinical studies are important to consider in this subgroup.

Extended Treatment

The secondary prevention of venous thromboembolism, recurrent VTE and extended anticoagulant treatment

Complications

The complications of VTE, including PTS and CTEPH

Cancer-Associated Thrombosis

Introduction to Cancer-Associated Thrombosis

Learn about the epidemiology of cancer-associated thrombosis and its risk factors

Treatment of Cancer-Associated Thrombosis

Find out how different anticoagulant regimens are used for the treatment of cancer-associated thrombosis and prevention of recurrent events

Arterial Thrombosis

Acute Coronary Syndrome

Introduction

An introduction to ACS and its diagnosis

Treatment

Treatment of ACS and assessing the risk of recurrence

Secondary Prevention

Secondary prevention in ACS covering anticoagulant, antiplatelet and adjunctive therapy

Coronary Artery Disease (CAD)

Introduction

An overview of coronary artery disease including definitions, epidemiology, and risk factors and prediction

Symptoms and Diagnosis

An overview of the symptoms and diagnosis of coronary artery disease

Treatment Guidelines

An overview of coronary artery disease management, including prevention of events, symptom relief and revascularization

Peripheral Artery Disease (PAD)

Introduction

An overview of peripheral artery disease including clinical presentation, progression, and risk factors

Symptoms and Diagnosis

An overview of the symptoms and diagnosis of peripheral artery disease

Treatment Guidelines

An overview of peripheral artery disease management, including lower extremity PAD, intermittent claudication, acute limb ischaemia and critical limb ischaemia