Bayer Pharma AG

Essence of this Article

Heart failure is an independent and major risk factor for venous thromboembolism (VTE), and coronary artery disease is a major cause of heart failure. Patients with heart failure who develop VTE have a worse prognosis relative to patients without the condition, and those who undergo hospitalization have an even greater risk of VTE. Both deep vein thrombosis (DVT) and pulmonary embolism (PE) are associated with significant mortality and morbidity in this population. The use of pacemakers, implantable defibrillators and central venous catheters are also linked to increased VTE risk.

Heart failure is a major risk factor for venous thromboembolism

In patients with heart failure, the risk of thrombosis is increased; however, its pathogenesis is poorly understood. Diminished blood flow in the dilated atria and ventricles is thought to be at least partially responsible for the development of thrombi,318 which can subsequently embolize and cause serious complications such as PE and stroke. Coronary artery disease is a major cause of heart failure – read more here.

Heart failure is an independent and major risk factor for VTE.319 Patients with heart failure who undergo hospitalization have an even greater risk of VTE.320 Without thromboprophylaxis, venographically proven DVT occurs in 10–22% of hospitalized patients with heart failure.321 Patients with heart failure who develop VTE have a worse prognosis relative to patients without the condition – both DVT and PE are associated with significant mortality and morbidity in this population.322 Other factors commonly associated with heart failure and linked to increased VTE risk include the use of pacemakers, implantable defibrillators and central venous catheters.323


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