The incidence of stroke in patients with atrial fibrillation (AF) is 2–17 times greater than in the general population, depending on the cause of AF. In addition, cardioembolic stroke is one of the most common complications of AF. The risk of stroke in patients with AF is also dependent on several risk factors, including age, with older patients being at higher risk. Several risk assessment tools are available to clinicians to help estimate the risk of stroke. One well-validated and widely-used tool is the CHA2DS2-VASc score, which identifies both major risk factors and clinically relevant non-major risk factors.