Coagulation, Direct Factor Xa, Factor Xa
Blood clot formation, or haemostasis, depends on an intricate series of events involving platelets, other cells, and the activation of specific blood proteins, known as coagulation factors.19
A thrombus is a blood clot formed when there is an imbalance in the blood coagulation system. A thrombus can block the flow of blood through a vein or an artery, and can detach from the vessel wall to become a life-threatening embolus when it lodges in the lungs or other vital organs.19, 372
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Based on preclinical and clinical trial data published to date, direct Factor Xa inhibitors have the potential to advance the field of anticoagulant therapy. Many features of direct Factor Xa inhibition make this a promising approach to the problem of thrombosis.
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The initiation of coagulation is divided into distinct parts: the extrinsic pathway and the intrinsic pathway.19 The extrinsic pathway is the primary initiator of coagulation, while the intrinsic pathway leads to the successive activation of Factors IX and X. Activated Factor X (Factor Xa) plays a central role in the coagulation cascade, as it occupies a point where the intrinsic and extrinsic pathways converge.
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See also: Apixaban
See also: Vitamin K Antagonist