Bayer Pharma AG

Enoxaparin, Enoxaparin Sodium, Fondaparinux

Enoxaparin, Enoxaparin Sodium

Unfractionated heparin (UFH) has been used for the prevention and treatment of thrombosis since the 1930s.101

Low-molecular-weight heparins (LMWHs), derived from UFH by depolymerisation, were introduced in Europe in the 1980s.101, 375 Because of several clinical advantages, LMWHs have gradually replaced UFH for most indications.103, 104

LMWHs in current use globally include enoxaparin, dalteparin, nadroparin, tinzaparin, certoparin, reviparin, and bemiparin.104

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The superior efficacy of LMWHs over UFH for the prevention of VTE after orthopedic surgery, and of fondaparinux over LMWHs, has been demonstrated in numerous large-scale randomized studies.25

Fondaparinux is a synthetic indirect inhibitor of Factor Xa. Its structure is based on the natural pentasaccharide contained within heparin and low-molecular-weight heparins (LMWHs). It potentiates the rate of neutralisation of Factor Xa by antithrombin. Unlike heparin, fondaparinux does not inactivate thrombin. In addition, fondaparinux does not inhibit Factor Xa bound in the prothrombinase complex and therefore does not completely inhibit Factor Xa. Long-term use is limited by the requirement of subcutaneous injection.25, 107

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Find out more about enoxaparin, enoxaparin sodium, and fondaparinux.

See also: Coagulation

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