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Enhanced pacemaker technology sharply reduced progression of nonpermanent atrial fibrillation to permanent AF in patients with bradycardia and sinus node disease in the large international, randomized MINERVA trial.
Once-daily edoxaban is noninferior to warfarin for prevention of stroke or systemic embolism; and genotype-guided dosing of warfarin may be beneficial, according to three studies published online Nov. 19 in the New England Journal of Medicine.
Patients better adhered to their medication regimens in the year following hospitalization for acute coronary syndrome (ACS) when they were part of a program that included personalized attention from a pharmacist compared with usual care, according to a study by P. Michael Ho, M.D., Ph.D., of the Denver VA Medical Center, and colleagues.
Pregnant women who enter the hospital for reasons unrelated to their pregnancy face a sharply increased risk for thromboembolism during their stay and several weeks thereafter, a new study suggests.
Doctors have known for years that atrial fibrillation (AF), or irregular heartbeat, increases the risk for stroke, but now researchers at Wake Forest Baptist Medical Center have shown that it also increases the risk for heart attack. In fact, for women and African Americans, it more than doubles the risk.
The risk of venous thromboembolism (VTE) in young trauma patients increased most dramatically from ages 16 to 21, findings that could help develop standardized protocols for VTE prophylaxis in pediatric trauma, researchers noted.
Emergency department patients with a pulmonary embolism or deep vein thrombosis can be treated as outpatients, growing evidence suggests.
By World Stroke Day 2013 (October 29) more than 500,000 people have shown their support for the Sign Against Stroke in Atrial Fibrillation campaign, calling for urgent coordinated action to avoid the thousands of preventable strokes that leave many atrial fibrillation (AF) patients disabled or dead every year.
Treatment of pulmonary embolism with rivaroxaban was associated with cost savings of more than $2,000 per patient compared with treatment with enoxaparin plus warfarin, according to new findings from the EINSTEIN-PE study.
In patients with left main or triple-vessel coronary artery disease, stent thrombosis after percutaneous coronary intervention (PCI) occurs with roughly the same frequency as graft occlusion following coronary artery bypass grafting (CABG). However, stent thrombosis is more likely to result in mortality in both the short and long term, according to 5-year results of the SYNTAX trial published online October 16, 2013, ahead of print in the Journal of the American College of Cardiology.
There are multiple independent risk factors for the development of deep venous thrombosis (DVT) and/or pulmonary embolism (PE) after spine surgery, according to a study published in the Oct. 1 issue of Spine.
New findings suggest that race or ethnic background is the primary factor in developing a common heart condition called atrial fibrillation.
The usefulness of postoperative venous thromboembolism (VTE) quality measures is limited by surveillance bias -- the more events you look for, the more you find, a study reports.
One third of patients who arrived at the emergency department with pulmonary embolism (PE) were misdiagnosed before being sent home or hospitalized, according to a retrospective observational study. Chronic lung conditions such as asthma frequently contributed to the delay in diagnosis.
Venous thromboembolism (VTE) rates in a prospective cohort of head and neck cancer surgical patients are higher than previously reported in retrospective studies, according to research published online Sept. 26 in JAMA Otolaryngology-Head & Neck Surgery.
In patients with atrial fibrillation (A-fib) treated with oral anticoagulation, the level of high-sensitivity troponin T independently predicts the risk of stroke and other ischemic outcomes as well as major bleeding, according to a substudy of the ARISTOTLE trial published online October 2, 2013, ahead of print in the Journal of the American College of Cardiology.
New data from a registry of patients with atrial fibrillation (AF) shows that stroke prevention therapy is far from optimal in clinical practice.
Chest pain is the classical symptom that usually directs diagnostic evaluation for heart attack. But as many as 35% of patients do not report chest pain.
Use of the CHA2DS2-VASc score markedly improves classification of atrial fibrillation patients who are truly at low risk of stroke, compared with the commonly used CHADS2 score, a German national study found.
In a new study, catheter ablation reduced the risk for stroke among patients with atrial fibrillation.
In patients with atrial fibrillation, delayed enhancement magnetic resonance imaging (DE-MRI) performed before ablative treatment can stage the degree of damaged heart tissue (atrial fibrosis) and help predict whether treatment will be successful or not […].
For patients with venous thromboembolism, treatment with edoxaban is non-inferior to warfarin with respect to recurrent symptomatic venous thromboembolism and is associated with significantly less bleeding, according to a study published online Sept. 1 in the New England Journal of Medicineto coincide with presentation at the annual European Society of Cardiology Congress, held from Aug. 31–Sept. 4 in Amsterdam.
Patients with heart valve replacements have greater rates of thromboembolic and bleeding complications after treatment with dabigatran compared with warfarin, according to a study published online Sept. 1 in theNew England Journal of Medicine to coincide with presentation at the annual European Society of Cardiology Congress, held from Aug. 31 to Sept. 4 in Amsterdam.
Emerging technology might provide a more personalized approach to help reduce the death and morbidity in atrial fibrillation patients, according to a European consensus statement.
Endogenous hypercortisolism is linked to increased VTE rates, and pathophysiologic data exist to suggest glucocorticoids increase clotting, but few studies have measured the clinical link between glucocorticoid administration and VTE events.
Children have double the risk of developing atrial fibrillation if a parent has this heart rhythm disorder, according to a study of participants in Framingham Heart Study.
Many patients with atrial fibrillation receive aspirin therapy besides oral anticoagulants, but concomitant aspirin therapy may be associated with increased risk for bleeding, according to an analysis of data from the ORBIT-AF registry.
Researchers from the Ottawa Health Research Institute have found that women with pre-eclampsia may also be at an increased risk of venous thromboembolism, also known as deep vein thrombosis – another potentially life-threatening condition.
People who have survived one thrombosis or pulmonary embolism are at risk of the event happening again. Researchers at the MedUni Vienna have now developed a “risk calculator” that enables doctors to estimate this risk more accurately.
Patients with rheumatoid arthritis were more likely to have other underlying conditions, like high blood pressure, diabetes, high cholesterol, heart failure and fractures, than were those in the comparison group.
The D-dimer test is often used to rule out the presence of venous thromboembolism; however, the test has been considered unreliable in postoperative patients because D-dimer levels may rise after surgery.
A new report on noninvasive testing for venous disease offers first-time guidance on dialysis access, as well as updated criteria for testing for venous insufficiency, deep vein thrombosis, and pulmonary embolism.
More than a third of patients with atrial fibrillation (AF) who were on oral anticoagulation in a large cohort study were also taking aspirin. Although most on aspirin also had some sort of vascular disease, the remaining 39% had no history of PCI, MI, cerebrovascular events, or other clinical cardiovascular disease that might justify aspirin use under the guidelines.
COPD patients presenting with PE have an increased risk for PE recurrences and fatal PE compared with those presenting with DVT alone. More efficient therapy is needed in this subtype of patients.
The routine use of computed tomography (CT) pulmonary angiography for the detection of pulmonary emboli has led to overdiagnosis of the condition, according to a new studypublished online July 2 in the BMJ.
Two different formulations of prothrombin complex concentrates (PCCs) showed promise as antidotes to rivaroxaban […], each in their own way, in a small study conducted in healthy volunteers.
Patients with venous thromboembolism (VTE) treated with the oral factor Xa inhibitor apixaban experienced similar outcomes to patients treated with enoxaparin and warfarin.
A new review finds a range of disparities in how men and women with ACS symptoms are treated and indicates that women who present with symptoms suggesting ACS need to be treated more aggressively.
New Thrombosis publications available for April, May and June 2013.
The evaluation shows that documented VTE risk assessment improved from less than 40% to >90% in the first nine months. As a result the proportion of hospital-associated thromobosis attributable to inadequate thromboprophylaxis fell significantly from 37.5% to 22.4%.
A more accurate and reliable stroke prediction model has been developed to help physicians decide whether to start blood-thinning treatment for patients with atrial fibrillation, as described in the current online issue of the Journal of the American Heart Association.
Laboratory studies suggest than hemostatic parameters and bleeding might be partially or completelycorrected by PCC for rivaroxaban better than dabigatran. Studies in humans suggest that PCC might reverse the effects of rivaroxaban better than dabigatran assessed by hemostatic tests.
Compared with other central venous catheters (CVCs), peripherally inserted central catheters (PICCs) more than doubled the risk of venous thromboembolism, a meta-analysis of studies recently revealed.
The causes of very late stent thrombosis are intensely debated, but new research leans toward a rupture in plaque buildup inside the stent.
Intermittent pneumatic compression with inflatable sleeves that fit over the legs reduced the occurrence of deep vein thrombosis (DVT) in immobile patients who had had a recent stroke in the CLOTS 3 study.
Using beta-blockers after heart surgery reduces the risk of dangerous abnormal heart rhythms, according to a analysis. One complication after heart surgery is atrial fibrillation (AF), where the two upper chambers of the heart quiver, rather than beating effectively.
Rivaroxaban […] has been approved in Europe for the prevention of atherothrombotic events (cardiovascular death, myocardial infarction or stroke) following an acute coronary syndrome (ACS). The drug was approved at a dose of 2.5 mg twice-daily and should be used in combination with standard antiplatelet therapy. Rivaroxaban is now the only oral anticoagulant to receive an ACS indication.
These contemporary observational worldwide data on non-valvular atrial fibrillation, collected at the end of the vitamin K antagonist-only era, indicate that these drugs are frequently not being used according to stroke risk scores and guidelines, with overuse in patients at low risk and underuse in those at high risk of stroke.
Systematic screening in GP practices for atrial fibrillation could identify more people with the disease than routine practice, according to a gold-standard review.
Low-dose aspirin is widely used as prevention for myocardial infarction and other cardiovascular diseases, but there is evidence that concurrent use of NSAIDs may inhibit the antiplatelet effect of aspirin.
Should recurrences after a failed ablation in patients with paroxysmal atrial fibrillation (AF) be treated with antiarrhythmic drugs (AAD) or with a repeat pulmonary vein isolation (PVI) procedure? More likely second time's the charm, suggests a randomized trial showing that repeat ablation is much more likely than AAD to get rid of a recurrence.